Production of 4-halo-3-hydroxybutyric acid

Abstract

PURPOSE: To produce a 4-halo-3-hydroxybutyric acid useful as a synthetic raw material for various drugs and physiologically active substances by using a bacterium. CONSTITUTION: A 4-halo-3-hydroxybutyronitrile is treated with a nitrile hydrolase derived from a bacterium belonging to the genus Arthrobacter, Nocardia, Pseudonocardia, Rhodococcus or Caseobacter to produce a 4-halo-3- hydroxybutyric acid. COPYRIGHT: (C)1992,JPO&Japio

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    JP-2003038194-AFebruary 12, 2003Mitsubishi Rayon Co Ltd, 三菱レイヨン株式会社Method of producing beta-hydroxy-gamma-butyro- lactones